Gama radijacija povećava apoptozu indukovanu kanabinolom, ne-psihoaktivnim kanabinoidom, u kulturi ćelija mieloblastične leukemije HL-60

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Gama radijacija povećava apoptozu indukovanu kanabinolom, ne-psihoaktivnim kanabinoidom, u kulturi ćelija mieloblastične leukemije HL-60
Časopis

Leukemia & Lymphoma

Godina 2003
Autori

Gallily R , Even-Chena T , Katzavian G , Lehmann D , Dagan A , Mechoulam R.

Institucija The Lautenberg Center for General and Tumor Immunology, The Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 1120, Israel
PubMed

PMID:14692532

Free text URL
Tip članka Laboratorijsko istraživanje In Vitro



Naslov originala

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells

Originalni apstrakt

Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line. Apoptosis was determined by staining with bisBenzimide and propidium iodide. A dose dependent increase of apoptosis was noted, reaching 61 and 43% with 8 microg/ml CBD and 15 microg/ml CBD-DMH, respectively, after a 24 h treatment. Prior exposure of the cells to gamma-irradiation (800 cGy) markedly enhanced apoptosis, reaching values of 93 and 95%, respectively. Human monocytes from normal individuals were resistant to either cannabinoids or gamma-irradiation. Caspase-3 activation was observed after the cannabinoid treatment, and may represent a mechanism for the apoptosis. Our data suggest a possible new approach to treatment of AML

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Prevod naslova

Gama radijacija povećava apoptozu indukovanu kanabinolom, ne-psihoaktivnim kanabinoidom, u kulturi ćelija mieloblastične leukemije HL-60

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