Kanabinoidi kao potencijalni antiepileptički lekovi

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Kanabinoidi kao potencijalni antiepileptički lekovi
Časopis

Current Opinions in Investigational Drugs

Godina 2005
Autori

Smith PF.

Institucija Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
PubMed

PMID:16044663

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Tip članka Pregledni članak



Naslov originala

Cannabinoids as potential anti-epileptic drugs

Originalni apstrakt

Cannabinoids have long been recognized as having the potential for both anticonvulsant and proconvulsant effects. The increased understanding of the cannabinoid receptors and their endogenous ligands over the last decade has provided a potential mechanism of action for these apparently paradoxical effects. Although the anticonvulsant effects of cannabinoids appear to be mediated by their action at presynaptic cannabinoid receptors, which inhibit the release of excitatory neurotransmitters such as glutamate, it is clear that they are also capable of producing proconvulsant effects through the activation of cannabinoid receptors on terminals releasing inhibitory neurotransmitters, such as gamma-amino-butyric acid. In the brain, the activation of cannabinoid receptors is carefully controlled by the rapid synthesis and degradation of endocannabinoids in a way that targets the endogenous ligands to specific sets of cannabinoid receptors. The potential problem in delivering a cannabinoid drug to treat epilepsy is the inability to control its actions at different cannabinoid receptors regulating the release of different neurotransmitters. Since the action of cannabinoids is complex, and there is a dearth of clinical trial data, it is currently unclear whether cannabinoids might be both efficacious and safe in the treatment of epilepsy.

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Prevod naslova

Kanabinoidi kao potencijalni antiepileptički lekovi

Prevod apstrakta

Kanabinoidi su odavno priznat kao supstance sa potencijalom i za antikonvulzivno i pro-konvulzivno dejstvo. Veće razumevanje kanabinoidnih receptora i njihovih endogenih liganda tokom poslednje decenije, pružilo nam je potencijalni mehanizam delovanja ovih naizgled paradoksalnih efekata. Iako izgleda da dejstvo kanabinoida na presinaptičke kanabidoindne receptore, koji inhibiraju sekreciju ekspersiju ekscitatornih neurotransmitera kao što je glutamat, posreduje u postizanju njihovog antikonvulzivnog efekta, jasno je da mogu proizvesti pro-konvulzivnne efekte kroz aktiviranje kanabinoidnih receptora na terminalima koji ekspresiraju inhibitorne neurotransmitere, kao što je gama-amino-buterna kiselina. U mozgu, aktivacija kanabinoidnih receptora je pažljivo kontrolisana putem brze sinteze i degradacije endokanabinoida gde se endogeni ligandi usmeravaju na određene skupove kanabinoidnih receptora. Potencijalni problem u davanju kanabinoidnog leka za lečenje epilepsije je nemogućnost kontrolisanja njegovog delovanja na različite kanabinoidne receptore koji regulišu oslobađanje različitih neurotransmitera. Pošto je dejstvo kanabinoida složeno, i postoji nedostatak podataka kliničkih ispitivanj, trenutno nije jasno da li bi kanabinoidi mogli biti efikasni i bezbedni u lečenju epilepsije .

* Ovo je neformalan prevod koji nije odobren od strane izdavača ni autora. Napisao ga je neko od korisnika sajta i najverovatnije ga nije pregledao stručni prevodilac.






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